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The series is based on the comic book of the same name published by Vertigo under DC. The 13-episode second season tells the story of preacher Jesse Custer (played by Dominic Cooper), who, upon learning that God has gone missing, sets out with his mentally unstable girlfriend Tulip (played by Ruth Negga) and Irish vampire Cassidy (played by Joseph Gilgun) to find him. However, the protagonists will not have an easy journey, as a murderer from hell will be chasing them.