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A pair of 12-year-old twin boys, Zack (Dylan Sprouse) and Cody (Cole Sprouse), along with their mother, are long-term residents of the upscale Tipton Hotel in Boston. Here, they meet new friends London (Brenda Song) and Maddie (Ashley Tisdale). Zack and Cody's continuous pranks turn the Tipton Hotel into their personal playground. While causing laughter, mischief, and chaos, they also take London and Maddie on a wild ride. Outrageous shenanigans ensue when the 12-year-old twin boys turn the upscale Boston hotel where they live (The Tipton) into their own personal playground. Living in a suite with their mom Carey, the boys often take their new friends London and Maddie along for the ride, as they cause mischief, mayhem, and various catastrophes in their elegant new digs.