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The film is based on the Disney theme park attraction "Jungle Cruise" and is set in the early 20th century, a time when ambitious adventurers roamed the world. Dr. Lily Houghton (Emily Blunt), a brave and fearless female scientist, journeys to the Amazon in search of a mystical tree with healing powers. She hires the carefree Frank (Dwayne Johnson) to lead her on this expedition. During this epic adventure, the seemingly mismatched pair encounters countless dangers and supernatural forces in the dense rainforest. However, as the secrets of this magical ancient tree are gradually revealed, the fates of Lily and Frank, as well as the fate of humanity, hang in the balance.