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Dr. Jae-hee (played by Kim Myung-min), a medical doctor turned pharmaceutical company employee, was once enticed by his brother Jae-bok (played by Kim Jong-wan) to invest in the stock market, resulting in a significant financial loss. Now, he works as a sales representative for a struggling pharmaceutical company, constantly bowing and scraping to clients, with his frustrations often directed at his family at home. Meanwhile, dozens of bodies are discovered along the Han River, all desiccated and in a horrifying state. The incident has widespread implications, affecting even those close to Jae-hee. Upon investigation, it is discovered that all the victims are infested with a parasite called gordian worm, which typically resides in insects. The gordian worm stimulates an increase in appetite in its host to absorb nutrients and, during its reproductive phase, causes the host to become disoriented and commit suicide by drowning, allowing the worm to reproduce in water. In the face of this novel mutation, humans are helpless, and the number of deaths is increasing exponentially, plunging Korea into chaos, akin to an apocalyptic scenario. With Jae-hee already overwhelmed by the struggles of making ends meet, how will he protect his family from this impending doom...