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In the 19th century, Romania was home to a mysterious region where humans and supernatural beings coexisted: Transylvania. In the town, a dark force ruled the area after dark, led by the vampire Dracula (Richard Roxburgh). They would emerge at night to commit brutal killings. Even more terrifying was that the group was growing stronger, and a bloodthirsty mad scientist had joined Dracula from afar. After multiple failed attempts to eradicate the evil, the Roman Catholic Church sent a vampire hunter, Van Helsing (Hugh Jackman), to America. On his way to Transylvania with his assistant, Van Helsing coincidentally saved another vampire hunter, Anna (Kate Beckinsale). Anna's family had been cursed by Dracula, leading to its destruction, and she had developed ghost-hunting skills from a young age. Anna and Van Helsing quickly joined forces to confront Dracula...