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One day, the shut-in NEET, Shizuma Shin, wakes up to find himself transformed into a "girl"! As Shin is confused by the sight of the beautiful young woman in the mirror, his scientist sister, Shizuma Mihori, who skipped grades to enter university, appears. She reveals that she added a strange drug to his drink! Shin has been a shut-in for the past two years, obsessively playing adult games at home and only reluctantly working when absolutely necessary. Suddenly finding himself living as a girl, Shin knows nothing about women's lives, such as toilets, bathrooms, skirts, bras, and more... He also meets his sister's middle school classmates, Hozuki Kaede and her younger sister, Hozuki Kaba. Shin's everyday life gradually becomes lively. In the midst of ongoing hardships, what will happen to the fate of the "former" brother...!