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The story revolves around a group of mad scientists who, driven by their dreams, develop a machine that can replicate Pokémon with just a small amount of genetic material. They use this machine to create a replica of the world's strongest Pokémon, which surpasses the capabilities of Mew. However, when the replicated Pokémon, known as Mewtwo, awakens, it becomes unstable due to its inability to find its true self. The leader of Team Rocket appears before Mewtwo and, using persuasive words, lures the confused Mewtwo into serving them. But soon after, Mewtwo once again feels lost and uncertain about its identity. Mewtwo returns to the island where it was created and decides to embark on a quest for revenge.